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Windows cannot access the specified device, path or file

You may get below error when you try to run SQL Server 2000 patch exe:-

Windows cannot access the specified device, path or file. You may not have appropriate permission to access the item

You have verified and have full access on all drives and are even Adim on box.

Then where is the issue? The issue is with the file properties.

You will see the file is blocked. This happens when you copy file from some remote location and there is some additional security setup on this server. Just click on UNBLOCK and click Apply. Try to run setup again at it will work.